How Do you all Organize your Homes...

I have a question how do you all Organize your Homes?
I am not talking about what Homemaking Book or Planner you may use.
I am talking about how do you all go through the things and decide what needs to go to the trash, to give away or needs to stay.
I am trying my best to organize our Darling Daughter's Room but it is getting so overwhelming I need some advice on how you all handle Organizing your Homes.